Trauma Research

HRI has recruited Dr. Margaret McKinnon as a Homewood Senior Scientist to provide leadership in building a clinical research and knowledge translation program in trauma at Homewood. Dr. McKinnon, who is working collaboratively with Homewood clinicians and HRI staff, also brings the expertise of her colleagues, Dr. Ruth Lanius and Dr. Paul Frewen.

Research in Development

Title:

Investigators:

Investing the Efficacy of a Top-Down Approach to Cognitive Remediation in Individuals with Affective Disorders McKinnon, Margaret; Lanius, Ruth; Boyd, Jenna; O’Connor, Charlene; Moniz, Sandy; Hood, Heather; Sousa, Sarah; Protopopescu, Alina
Post-traumatic Stress Disorder and its Dissociative Subtype in Military Personnel and Veterans Lanius, Ruth; McKinnon, Margaret; Admon, Roee; Foster, Jane; Frewen, Paul; Fruchter, Eyal; Gonzalez, Andrea; Jetly, Rakesh; McCabe, Randi E; Neufeld, Richard; Rhind, Shawn; Richardson, Don; Theberge, Jean
Randomized controlled trial of mindfulness meditation for PTSD with or without neurofeedback augmentation Frewen, Paul; Lanius, Ruth; McKinnon, Margaret; Neufeld, Richard; Thabane, Lehana; Theberge, Jean

Publications

2016

Gender differences in perceived causal relations between trauma-related symptoms and eating disorders in online community and inpatient samples
Thornley, Elizabeth • Vorstenbosch, Varerie • Frewen, Paul

Dissociative symptoms are associated with reduced neuropsychological performance in patients with recurrent depression and a history of trauma exposure

Parlar, Melissa · Frewen, Paul A. · Oremus, Carolina · Lanius, Ruth A. · McKinnon, Margaret C.

The innate alarm circuit in post-traumatic stress disorder: Conscious and subconscious processing of fear- and trauma-related cues

Rabellino, Daniela · Densmore, M. · Frewen, Paul A. · Thebérge, Jean · Lanius, Ruth A.

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Thome, Janine · Densmore, Maria · Frewen, Paul A. · McKinnon, Margaret C. · Théberge, Jean · Nicholson, Andrew

Parental bonding and neuropsychological performance are associated with episodic simulation of future events in trauma-exposed patients with major depressive disorder

Parlar, Melissa · Lee, Alex · Haggee, Zeeshan · Rhooms, Latisha · Lanius, Ruth A. · McKinnon, Margaret C.

Methylene blue treatment for residual symptoms of bipolar disorder: Randomised crossover study

Alda, Martin · McKinnon, Margaret C. · Blagdon, Ryan · Garnham, Julie · MacLellan, Susan · O’Donovan, Claire · Hajek, Tomas · Nair, Cynthia · Dursun, Serdar · Macqueen, Glenda

A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions

McKinnon, Margaret C. · Boyd, Jenna E. · Frewen, Paul A. · Lanius, Ulrich · Jetly, Rakesh Richardson, Judith D. · Lanius, Ruth A.

Overcoming the challenges inherent in conducting design research in mental health settings: Lessons from St. Joseph’s healthcare, Hamilton’s pre and post-occupancy evaluation
Ahern, Catherine • McKinnon, Margaret C. • Bieling, Peter J. • McNeely, Heather • Langstaff, Karen

2015

The relation between morality and mental health in the North American military forces
Nazarov, Anthony • McNeely, Heather • Kiang, Michael • Lanius, Ruth A. • McKinnon, Margaret C.

Restoring large-scale brain networks in PTSD and related disorders: A proposal for neuroscientifically-informed treatment interventions
Lanius, Ruth A.Frewen, Paul A. • Tursich, Mischa • Jetly, Rakesh • McKinnon, Margaret C.

The relationship between insight and autobiographical memory for emotional events in schizophrenia
MacDougall, Arlene G. • McKinnon, Margaret C. • Herdman, Katherine A. • King, Matthew J. • Kiang, Michael

Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype
Frewen, Paul A. • Brown, Matthew F. • Steuwe, Carolin • Lanius, Ruth A.

Comprehension of affective prosody in women with post-traumatic stress disorder related to childhood abuse
Nazarov, Anthony • Frewen, Paul A. • Oremus, Carolina • Schellenberg, E. Glenn • McKinnon, Margaret C.Lanius, Ruth A.

Effect of direct eye contact in women with PTSD related to interpersonal trauma: Psychophysiological interaction analysis of connectivity of an innate alarm system
Steuwe, Carolin • Daniels, Judith K. • Frewen, Paul A. • Densmore, Maria • Théberge, Jean • Lanius, Ruth A.

Effects of electroconvulsive therapy on cognitive functioning in patients with depression: Protocol for a systematic review and meta-analysis
Oremus, Carolina • Oremus, Mark • McNeely, Heather • Losier, Bruno • Parlar, Melissa • King, Matthew • Hasey, Gary • Fervaha, Gagan • Graham, Allyson C. • Gregory, Caitlin • Hanford, Lindsay • Nazarov, Anthony • Restivo, Maria • Tatham, Erica • Truong, Wanda • Hall, Geoffrey B. • Lanius, Ruth A.McKinnon, Margaret C.

Trauma and PTSD: setting the research agenda
Olff, Miranda • Armour, Cherie • Brewin, Chris • Cloitre, Marylene • Ford, Julian D. • Herlihy, Jane • Lanius, Ruth A. • Rosner, Rita • Schmidt, Ulrike • Turner, Stuart

Trauma-related dissociation and altered states of consciousness: A call for clinical, treatment, and neuroscience research
Lanius, Ruth A.

The neural correlates of memory for a life-threatening event: An fMRI study of passengers from flight AT236
Palombo, Daniela J. • McKinnon, Margaret C. • McIntosh, Anthony R. • Anderson, Adam K. • Todd, Rebecca M. • Levine, Brian

Threat of death and autobiographical memory: A study of passengers from flight AT236
McKinnon, Margaret C. • Palombo, Daniela J. • Nazarov, Anthony • Kumar, Namita • Khuu, Wayne • Levine, Brian

Treatment of complex dissociative disorders: A comparison of interventions reported by community therapists versus those recommended by experts
Myrick, Amie C. • Chasson, Gregory S. • Lanius, Ruth A. • Leventhal, Barry • Brand, Bethany L.

Distinct intrinsic network connectivity patterns of post-traumatic stress disorder symptom clusters
Tursich, Mischa • Ros, Tomas • Frewen, Paul A. • Kluetsch, Rosemarie C. • Calhoun, Vince D. • Lanius, Ruth A.

Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder
Daniels, Judith K. • Frewen, Paul A. • Théberge, Jean • Lanius, Ruth A.

Role of morality in the experience of guilt and shame within the armed forces
Nazarov, Anthony • Jetly, Rakesh • McNeely, Heather • Kiang, Michael • Lanius, Ruth A.McKinnon, Margaret C.

The dissociative subtype of posttraumatic stress disorder: Unique resting-state functional connectivity of basolateral and centromedial amygdala complexes
Nicholson, Andrew A. • Densmore, Maria • Frewen, Paul A. • Théberge, Jean • Neufeld, Richard W. • McKinnon, Margaret C.Lanius, Ruth A.

Dissociation in borderline personality disorder: Disturbed cognitive and emotional inhibition and its neural correlates
Winter, Dorina • Krause-Utz, Annegret • Lis, Stefanie • Chiu-De, Chiu • Lanius, Ruth A. • Schriner, Friederike • Bohus, Martin • Schmahl, Christian

Trauma-related altered states of consciousness (TRASC) and functional impairment I: Prospective study in acutely traumatized persons
Frewen, Paul A. • Hegadoren, Kathy • Coupland, Nick • Rowe, Brian • Neufeld, Richard • Lanius, Ruth A.

Emotional memory in pregnant women at risk for postpartum depression
Williams, Marissa E. • Becker, Suzanna • McKinnon, Margaret C. • Wong, Queenie • Cudney, Lauren E. • Steiner Meir • Frey, Benicio N.

Intrinsic connectivity networks in post-traumatic stress disorder during sub- and supraliminal processing of threat-related stimuli
Rabellino, Daniela • Tursich, Mischa • Frewen, Paul A. • Daniels, Judith K. • Densmore, Maria • Théberge, Jean • Lanius, Ruth A.

The innate alarm circuit in post-traumatic stress disorder: Conscious and subconscious processing of dear- and trauma-related cues
Rabellino, Daniela • Densmore, M. • Frewen, Paul A. • Thebérge, Jean • Lanius, Ruth A.

2014

Effect of direct eye contact in PTSD related to interpersonal trauma: An fMRI study of activation of an innate alarm system
Steuwe, Carolin • Daniels, Judith K. • Frewen, Paul A. • Densmore, Maria • Pannasch, Sebastian • Beblo, Thomas • Reiss, Jeffrey • Lanius, Ruth A.

A systematic review of the reporting of sample size calculations and corresponding data components in observational functional magnetic resonance imaging studies
Guo, Qing • Thabane, Lehana • Hall, Geoffrey • McKinnon, Margaret C. • Goeree, Ron • Pullenayegum, Eleanor

Theory of mind performance in women with posttraumatic stress disorder related to childhood abuse
Nazarov, Anthony • Frewen, Paul A. • Parlar, Melissa • Oremus, Carolina • MacQueen, Glenda • McKinnon, Margaret C.Lanius, Ruth A.

The reporting of observational clinical functional magnetic resonance imaging studies: A systematic review
Guo, Qing • Parlar, Melissa • Truong, Wanda • Hall, Geoffrey • Thabane, Lehana • McKinnon, Margaret C. • Goeree, Ron • Pullenayegum, Eleanor

Alterations in empathic responding among women with posttraumatic stress disorder associated with childhood trauma
Parlar, Melissa • Frewen, Paul A. • Nazarov, Anthony • Oremus, Carolina • MacQueen, Glenda • Lanius, Ruth A.McKinnon, Margaret C.

Resting-state neuroimaging studies: A new way of identifying differences and similarities among the anxiety disorders?
Peterson, Andrew • Thome, Janine • Frewen, Paul A.Lanius, Ruth A.

Association of trauma exposure with proinflammatory activity: A transdiagnostic meta-analysis
Tursich, Mischa • Neufeld, Richard W. • Frewen, Paul A. • Harricharan, S • Kibler, Jeffrey L. • Rhind, Shawn G. • Lanius, Ruth A.

A social-cognitive-neuroscience approach to PTSD: Clinical and research perspectives
Lanius, Ruth A.Frewen, Paul A. • Nazarov, Anthony • McKinnon, Margaret C.

Plastic modulation of PTSD resting-state networks and subjective wellbeing by EEG neurofeedback
Kluetsch, Rosemarie C. • Ros, Tomas • Théberge, Jean • Frewen, Paul A. • Calhoun, Vince D. • Schmahl, Christian • Jetly, Rakesh • Lanius, Ruth A.

Trauma-related altered states of consciousness: Exploring the 4-D model
Frewen, Paul A. Lanius, Ruth A.

Trauma-related altered states of consciousness in women with BPD with or without co-occurring PTSD
Frewen, Paul A. • Kleindienst, Nikolaus • Lanius, Ruth • Schmahl, Christian

Test-retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia
Boyd, Jenna E. • Patriciu, Iulia • McKinnon, Margaret C. • Kiang, Michael

Chronic complex dissociative disorders and borderline personality disorder: Disorders of emotion dysregulation?
Brand, Bethany L. • Lanius, Ruth A.

Altered connectivity within the salience network during direct eye gaze in PTSD
Thome, Janine • Frewen, Paul A. • Daniels, Judith K. • Densmore, Maria • Lanius, Ruth A.

Tuning pathological brain oscillations with neurofeedback: A systems neuroscience framework
Ros, Tomas • Baars, Bernard J. • Lanius, Ruth A. • Vuilleumier, Patrik