Addictions Research

Homewood Research Institute is conducting addictions research focused on improving practice and outcomes. Dr. James MacKillop, Homewood Senior Scientist and Peter Boris Chair in Addictions Research at McMaster University, is guiding the development of the research program with Homewood clinical leaders and HRI staff.



Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability
Bidwell, L.C.· Gray, J.C.· Weafer, J. · Palmer, A.A. · de Wit, H. · MacKillop, J

Pathways Linking Adverse Childhood Experiences to Cigarette Smoking Among Young Black Men: a Prospective Analysis of the Role of Sleep Problems and Delayed Reward Discounting
Oshri, A. · Kogan, S.M. · Liu, S. · Sweet, L. · MacKillop, J

Integrating psychological and pharmacological treatments for addictive disorders
MacKillop, James ·Kenna, George A.· Leggio, Lorenzo · Ray, Lara A.

Association between cannabis use and methadone maintenance treatment outcomes: an investigation into sex differences
Zielinski, Laura. · Bhatt, Meha · Sanger, Nitika · Plater, Carolyn · Worster, Andrew · Varenbut, Michael · Daiter, Jeff · Pare, Guillaume · Marsh, David C. · Desai, Dipika · MacKillop, James · Steiner, Meir · McDermid Vaz, Stephanie · Thabane, Lehana · Samaan, Zainab

The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy
Naji, Leen · Dennis, Brittany · Bawor, Monica · Varenbut, Michael · Daiter, jeff · Plater, Carolyn · Pare, Guillaume · Marsh, David C. · Worster, Andrew · Desai, Dipika · MacKillop, James · Thebane, Lehana · Samaan, Zainab

Latent factor structure of a behavioral economic marijuana demand curve
Aston, Elizabeth · Farris, Samantha G. · MacKillop, James · Metrik, Jane

Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders
Murphy, Cara · MacKillop, James · Martin, Rosemarie A. · Tidey, Jennifer W. · Colby, Suzanne M. · Rohsenow, Damaris J.

Relative reinforcing value of food and delayed reward discounting in obesity and disordered eating: A systematic review
Stojek, Monika Magdalena Kardacz · MacKillop, James

The influence of substance use on depressive symptoms among young adult black men: The sensitizing effect of early adversity: Depressive Symptoms and Substance Use in Black Men
Kogan, Steven · Cho, Junhan · Oshri, Assaf · MacKillop, James

Self-control depletion and nicotine deprivation as precipitants of smoking cessation failure: A human laboratory model
Heckman, Bryan W. · Alderson MacQueen, David · Marquinez, Nicole S. · MacKillop, James · Bickel, Warren K. · Brandon, Thomas H.

The Neuroeconomics of Tobacco Demand: An Initial Investigation of the Neural Correlates of Cigarette Cost-Benefit Decision Making in Male Smokers
Gray, Joshua Charles · Amlung, Michael · Owens, Max Michael · Acker, John · Brown, Courtney, L. · Brody, Gene H. · Sweet, Lawrence H. · MacKillop, James

Neural Correlates of Graphic Cigarette Warning Labels Predict Smoking Cessation Relapse
Owens, Max Michael · MacKillop, James · Gray, Joshua Charles · Hawkshead, Brittany E. · Murphy, Cara M. · Sweet, Lawrence H.

Cannabinoid receptor gene polymorphism (rs2023239) associated with demand for marijuana
Aston, Elizabeth · Knopik, Valerie S. · McGeary, John · MacKillop, James · Metrik, Jane

Multidimensional Assessment of Impulsivity in Relation to Obesity and Food Addiction
VanderBroek-Stice, Lauren · Stojek, Monika Magdalena Kardacz · Beach, Steven R. H. · Vandellen, Michelle R. · MacKillop, James

Family-centered prevention ameliorates the longitudinal association of poverty with hippocampal and amygdalar volumes in adulthood
Brody, G.H. · Gray, J. · Yu, T. · Barton, A.W. · Beach, S.R.H. · Galván, A. · MacKillop, J. · Windle, M. · Chen, E. · Miller, G.E. · Sweet, L.H.


Syntax for calculation of discounting indices from the Monetary Choice Questionnaire and Probability Discounting Questionnaire
Gray, Joshua C.  ·  Amlung, Michael T. ·  Palmer, Abraham A. · MacKillop,  James 

Initial examination of priming tasks to decrease delay discounting
Sheffer, Christine E. · MacKillop, James · Fernandez, Arislenia · Christensen, Darren · Bickel, Warren K. · Johnson, Matthew W. · Panissidi, Luana · Pittman, Jami · Franck, Christopher T. · Williams, Jarrett · Mathew, Merlin 

Delay discounting and addiction:  A critical review and identification of emerging priorities
Amlung, Michael · MacKillop, James

Commentary: Delay discounting and smoking: robust correlation, but uncertain causation
MacKillop, James  · Munafo, Marcus R.

Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol
Zielinski, Laura. · Bhatt, Meha · Eisen, Rebecca · Perera, Stefan · Bhatnagar, Neera · MacKillop, James · Steiner, Meir · McDermid Vaz, Stephanie · Thabane, Lehana · Samaan, Zainab

The Substitutability of Cigarettes and Food: A Behavioral Economic Comparison in Normal Weight and Overweight or Obese Smokers
Murphy, Cara · Owens, Max Michael · Sweet, Lawrence H. · MacKillop, James

Interrelationships between Marijuana Demand and Discounting of Delayed Rewards: Convergence in Behavioral Economic Methods
Aston, Elizabeth · Metrik, Jane · Amlung, Michael · Kahler, Christopher W. · MacKillop, James

Adaptation of an Acute Psychiatric Unit to a Concurrent Disorders Unit to Increase Capacity and Improve Patient Care
Raymond, H. · Amlung, Michael · De Leo, Joseph A. · MacKillop, James

Cue-Elicited Increases in Incentive Salience for Marijuana: Craving, Demand, and Attentional Bias
Metrik, Jane · Aston, Elizabeth · Kahler, Christopher W. · Rohsenow, Damaris J. · McGeary, John E. · Knopik, Valeria S. · MacKillop, James

The latent structure of impulsivity: impulsive choice, impulsive action, and impulsive personality traits
MacKillop, James · Weafer, Jessica · Gray, Joshua Charles · Oshri, Assaf · Palmer, Abraham A. · de Wit, Harriet

Steep Delay Discounting and Addictive Behavior: A Meta-Analysis of Continuous Associations: Delay discounting and addiction
Amlung, Michael · Vedelago, Lana · Acker, John · Balodis, Iris · MacKillop, James

Associations between nicotine dependence, anhedonia, urgency and smoking motives
Roys, Melanie · Weed, Keri · Carrigan, Maureen · MacKillop, James

Corrigendum to “DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers” [Pharmacol. Biochem. Behav. 102 (2012) 471–476]
Wahlstrom, Laura C. · McChargue, Dennis E. · MacKillop, James

Steep discounting of delayed monetary and food rewards in obesity: A meta-analysis
Amlung, Michael T. • Petker, T. • Jackson, J. • Balodis, M. • MacKillop, James

Interactive relationships between sex-related alcohol expectancies and delay discounting on risky sex
Celio, Mark A. • MacKillop, James • Caswell, Amy J. • Mastroleo, Nadine R. • Kahler, Christopher W. • Barnett, Nancy P. • Colby, Suzanne M. • Operario, Don • Monti, Peter M.

The behavioral economics and neuroeconomics of alcohol use disorders
MacKillop, James 

Interrelationships among parental family history of substance misuse, delay discounting, and personal substance use
VanderBroek, Lauren • Acker, John • Palmer, Abraham A. • de Wit, Harriet • MacKillop, James

Attention deficit hyperactivity disorder and monetary delay discounting: A meta-analysis of case-control studies
Jackson, Jacob N. S. • MacKillop, James


Behavioral economic analysis of stress effects on acute motivation for alcohol
Owens, Max M. • Ray, Lara A. • MacKillop, James

Willingness to provide support for a quit attempt: A study of partners of smokers
van Dellen, Michelle R. • Boyd, Sara M. • Ranby, Krista W. • MacKillop, James • Lipkus, Isaac M.

Behavioral economic decision making and alcohol-related sexual risk behavior
MacKillop, James • Celio, Mark A. • Mastroleo, Nadine R. • Kahler, Christopher W. • Operario, Don • Colby, Suzanne M. • Barnett, Nancy P. • Monti, Peter M.

Using behavior economics to understand alcohol use disorders: A concise review and identification of research priorities
Gray, Joshua C. • MacKillop, James

D-cycloserine to enhance extinction of cue-elicited craving for alcohol: A translational approach
MacKillop, James • Few, Lauren R. • Stojek, Monika K. • Murphy, Cara. M. • Malutinok, Shannen. F. • Johnson, Fiona T. • Hofmann, Stefan. G. • Swift, Robert. M. • McGreary, John E. • Monti, Peter M.

Further evidence of close correspondence for alcohol demand decision making for hypothetical and incentivized rewards
Amlung, Michael T. • MacKillop, James

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence
Bidwell, L. Cinnamon • McGeary, John E. • Gray, Joshua C. • Palmer, Rohan H. C. • Knopik, Valerie S • MacKillop, James

Area under the curve as a novel metric of behavioral economic demand for alcohol
Amlung, Michael T. • Yurasek, Ali • McCarty, Kayleigh N. • MacKillop, James • Murphy, James G.

Initial development of a brief behavioral economic assessment of alcohol demand
Owens, Max M. • Murphy, Cara M. • MacKillop, James

The relationship between alcohol consumption, perceived stress, and CRHR1 genotype on the hypothalamic-pituitary-adrenal axis in rural African Americans
Obasi, Ezemenari M. • Shirtcliff, Elizabeth A. • Brody, Gene H. • MacKillop, James • Pittman, Delishia M. • Cavanagh, Lucia • Philibert, Robert A.

Further validation of a marijuana purchase task
Aston, Elizabeth R. • Metrik, Jane • MacKillop, James

Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: A critical evaluation
Gray, Joshua C. • MacKillop, James

Stress, cues, and eating behavior: Using drug addiction paradigms to understand motivation for food
Stojek, Monika K. • Fischer, Sarah F. • MacKillop, James

Genetic influences on delay discounting in smokers: Examination of a priori candidates and exploration of dopamine-related haplotypes
MacKillop, James • Gray, Joshua C. • Bidwell, L. Cinnamon • Bickel, Warren K. • Sheffer, Christine E. • McGreary, John E.

NCAM1-TTC12-ANKK1-DRD2 polymorphisms and smoking motives as intermediate phenotypes for nicotine dependence
Bidwell, L. Cinnamon • McGeary, John E. • Gray, Joshua C. • Palmer, Rohan H. C. • Knopik, Valerie S • MacKillop, James

Predictive validity of a cigarette purchase task in a randomized controlled trial of contingent vouchers for smoking in individuals with substance use disorders
MacKillop, James • Murphy, Cara M. • Martin, Rosemarie A. • Stojek, Monika • Tidey, Jennifer W. • Colby, Suzanne M. • Rohsenow, Damaris J.

An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans
Bidwell, L. Cinnamon • McGreary, John E. • Palmer, Rohan H. C. • Knopik, Valerie S. • MacKillop, James

Childhood physical and sexual abuse and social network patterns on social media: Associations with alcohol use and problems among young adult women
Oshiri, Assaf • Himelboim, I. • Kwon, Josephine A. • Sutton, Tara E. • MacKillop, James

A social network analysis approach to alcohol use and co-occurring addictive behavior in young adults
Meisel, Matthew K. • Clifton, Allan D. • MacKillop, James • Goodie, Adam S.

Behavioral economic predictors of brief alcohol intervention outcomes
Murphy, James G. • Dennhardt, Ashley A. • Yurasek, Ali M. • Skidmore, Jessica R. • Martens, Matthew P. • MacKillop, James • McVeditt-Murphy, Meghan E.


Biobehavioral mechanisms of topiramate’s effects on alcohol use: An investigation pairing laboratory and ecological momentary assessments
Miranda, Robert • MacKillop, James • Treloar, Hayley • Blanchard, Alexander • Tidey, Jennifer W. • Swift. Robert M. • Chun, Thomas • Rohsenow, Damaris J. • Monti, Peter M.